Sulfinpirazon

SULFINPIRAZON (Sulfinpyrazone) *. 1, 2-Difenil-1, 4-[2 - (fenilsulfinil) - ethyl] -3, 5-pirazolidindion.

Synonyms : Anturan, Anturan, Anturanil, Anturidin, Enturan, Pyrocard, Sulfazone, Sulfizone and others.

He is one of the metabolites butadiona (see).

Express analgeticheskogo and antiinflammatory actions will not help, but an active urikozuricheskim funds.

Applied to treat gout. Enhance the allocation of uric acid through the kidneys, especially in the first stage of treatment.

The drug is well absorbed. Duration of a single dose of 8 - 12 hours Since the drug has not analgeticheskogo action to appoint a nenarkoticheskie analgetiki (Phenylbutazone or etc.).

Assign inside usually a daily dose of 0.3 - 0.4 g (2 - 4 admission). Adopt after eating; Preferably zapivat milk.

Usually sulfinpirazon well tolerated, but may increase gastric ulcer and duodenal ulcer.

Early treatment may increase in gout attacks. In appointing the treatment must first enter the body enough liquid to alkalinization of urine (reception gidrokarbonata sodium); In response urine acidic deposition may concrements in the urinary track.

Contraindications : gastric ulcer disease and gastrointestinal cancer, increased sensitivity to pirazolona derivative (see Phenylbutazone), heavy damage liver and kidneys.

Please note that the small doses salitsilatov weaken urikozuricheskoe sulfinpirazona effect. Effects of oral anticoagulants, oral antidiabetics funds sulfanilamidov, penicillin drug increases (see Etamid).

Product : pills to 0.1 g. In higher doses sulfinpirazon reduces aggregation and adgezivnost platelets. As antiagregatsionnoe tool (see Antiagreganty) applied in the form of pills to 0.2 g; Nominated for 1 - 2 4 pills twice a day (800 mg / day). Applied to patients after myocardial infarction (starting after 4 weeks of treatment after a heart attack)